Question 1. An Ames dwarf mouse was born with testosterone receptor deficiency. The chromosomal sex of this mouse is not known but it showed female external genitalia and distinct mammary glands with clear nipples. During adult life, the animal showed no estrous cycle. The mouse was injected with estradiol and progesterone to prepare the uterus followed by artificial insemination. The mouse failed to develop pregnancy or mammary gland growth. Discuss the significance of these findings in relation to sexual differentiation of the reproductive system, reproduction and mammary gland development.
Question 2: Please read the following case and answers the questions:
The case: A 16 years old female patient was seen in the adolescent clinic with the complaint of excessive sweating, dry skin, discomfort in her neck, lack of sleep at night, 2 lbs of weight loss, felling nervous for the past 10 – 12 days. Prior to this visit, her mother called the clinic and shared her concerns about the patient might be pregnant and, according to the mother, “She has been hanging out with bad company”.
Points need to be addressed:
1. What specific questions will you ask to get more pertinent information in this case?
2. What family history would you like to know?
3. What physical examination is most pertinent to this case?
4. What lab tests will you order?
5. Discuss the possible etiology of the problem after the lab finding.